Tranilast suppresses intimal hyperplasia after photochemically induced endothelial injury in the rat
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چکیده
منابع مشابه
Zinc reduces intimal hyperplasia in the rat carotid injury model.
BACKGROUND The response to arterial injury following balloon dilatation is known to involve proliferative and inflammatory processes. The current widespread use of stents to maintain arterial patency not only does not eliminate but possibly exaggerates the proliferative and inflammatory phenotype and although drug-eluting stents are available, their long-term safety is yet to be determined. Zin...
متن کاملPhotochemically induced endothelial injury in the mouse as a screening model for inhibitors of vascular intimal thickening.
We have established a mouse model of intimal thickening and assessed its suitability for experimental studies of intimal thickening. Neointimal formation was observed after endothelial injury by photochemical reaction between transluminal green light and systemically administered rose Bengal, which represents a nonmechanical approach to vessel wall denudation. Intimal thickening began 7 days af...
متن کاملEndothelial implants inhibit intimal hyperplasia after porcine angioplasty.
The perivascular implantation of tissue-engineered endothelial cells around injured arteries offers an opportunity to study fundamental vascular physiology as well as restore and improve tissue function. Cell source is an important issue because the ability to implant either xenogeneic or allogeneic cells would greatly enhance the clinical applications of tissue-engineered grafts. We investigat...
متن کاملThe effect of anagliptin on intimal hyperplasia of rat carotid artery after balloon injury
The present study evaluated the effect of anagliptin on intimal hyperplasia following carotid artery injury in Sprague‑Dawley rats. Sprague‑Dawley rats weighing 280‑300 g were injured using a 2F Fogarty balloon embolectomy catheter. The rats were divided into injury‑(saline) and anagliptin‑(10 mg/kg/day) treated groups. vascular injuries were induced in the left carotid artery, followed by eval...
متن کاملLate-outgrowth endothelial cells attenuate intimal hyperplasia contributed by mesenchymal stem cells after vascular injury.
OBJECTIVE Mesenchymal stem cells (MSCs) are one of a number of cell types undergoing extensive investigation for cardiac regeneration therapy. It has not yet been determined whether this cell therapy also substantially contributes to vascular remodeling of diseased vessels. METHODS AND RESULTS Human MSCs and a variety of progenitor and vascular cells were used for in vitro and in vivo experim...
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ژورنال
عنوان ژورنال: European Journal of Pharmacology
سال: 1996
ISSN: 0014-2999
DOI: 10.1016/0014-2999(95)00636-2